Subject(s)
Fever of Unknown Origin , Infections/diagnosis , Algorithms , Animals , Cross Infection/complications , Cross Infection/diagnosis , Diagnosis, Differential , Drug-Related Side Effects and Adverse Reactions , Fever of Unknown Origin/etiology , Hematologic Neoplasms/complications , Hematologic Neoplasms/diagnosis , Humans , Immunocompromised Host , Infections/complications , Surgical Procedures, Operative/adverse effects , Zoonoses/complications , Zoonoses/diagnosisSubject(s)
Arthritis, Juvenile/diagnosis , Hirschsprung Disease/complications , Antirheumatic Agents/therapeutic use , Arthritis, Juvenile/complications , Arthritis, Juvenile/drug therapy , Child Development , Diagnosis, Differential , Fever of Unknown Origin/etiology , Humans , Infant , Interleukin 1 Receptor Antagonist Protein/therapeutic use , Joints/diagnostic imaging , Knee/diagnostic imaging , Lymph Nodes/diagnostic imaging , Magnetic Resonance Imaging , Male , Tomography, X-Ray Computed , UltrasonographyABSTRACT
A 40-year-old woman presented with fever of unknown origin (FUO) for 2 months. Without a definitive diagnosis and having received multiple empirical antibiotics from outside without relief, she was referred to our centre. Cardiac auscultation was remarkable for a grade 3/6 continuous murmur in the upper left sternal border. Echocardiogram revealed a patent ductus arteriosus (PDA) and a 5×7 mm mobile vegetation at the pulmonary artery bifurcation. Blood culture grew Streptococcus mutans. Embolisation of the vegetation to the pulmonary circulation occurred after the start of intravenous antibiotics resulting in fever relapse. Antibiotics were continued for 6 weeks and the fever settled. She underwent device closure of PDA after 12 weeks and is currently doing fine. Infective endocarditis/endarteritis is an important differential in a patient of FUO. A thorough clinical examination is important in every case of FUO, gives an important lead into diagnosis and guides appropriate investigations to confirm it.
Subject(s)
COVID-19 , Ductus Arteriosus, Patent , Endarteritis , Fever of Unknown Origin , Adult , Ductus Arteriosus, Patent/diagnosis , Ductus Arteriosus, Patent/diagnostic imaging , Endarteritis/diagnosis , Female , Fever of Unknown Origin/etiology , Humans , Pandemics , SARS-CoV-2ABSTRACT
In this case series, we describe the clinical course and outcomes of 7 febrile infants aged ≤60 days with confirmed severe acute respiratory syndrome coronavirus 2 infection. No infant had severe outcomes, including the need for mechanical ventilation or ICU level of care. Two infants had concurrent urinary tract infections, which were treated with antibiotics. Although a small sample, our data suggest that febrile infants with severe acute respiratory syndrome coronavirus 2 infection often have mild illness.